Epigenetics

Lectures connecting senescence, p53 biology, metabolism, epigenetics and aging-related pathophysiology for Master-level biology and health students.

Dissecting how p53-associated metabolic programs, pyruvate metabolism and acetyl-CoA production shape chromatin states and stabilize senescence during aging.

Time-resolved multi-omic analyses of senescence to identify regulatory hierarchies, chromatin transitions and vulnerabilities in aging and cancer.