https://www.pierre-francois-roux.com/tags/time-course/ Recent content in Time course on Pierre-François Roux Hugo -- gohugo.io en-us © 2021 Pierre-François Roux Fri, 19 Jun 2026 09:00:00 +0000 https://www.pierre-francois-roux.com/2026/06/19/think-in-trajectories-not-only-in-contrasts/ Fri, 19 Jun 2026 09:00:00 +0000 https://www.pierre-francois-roux.com/2026/06/19/think-in-trajectories-not-only-in-contrasts/ Differential expression is often framed as a list of pairwise contrasts: treated versus control, late versus early, condition A versus condition B. That is useful, but it can flatten a time-course experiment into disconnected snapshots. When samples are ordered in time, a better first question is: which genes follow similar trajectories? A transient pulse, a delayed induction and a progressive repression can all have the same fold change in one contrast, but they usually mean different biology.