https://www.pierre-francois-roux.com/tags/systems-biology/ Recent content in Systems biology on Pierre-François Roux Hugo -- gohugo.io en-us © 2021 Pierre-François Roux Fri, 19 Jun 2026 00:00:00 +0000 https://www.pierre-francois-roux.com/project/skin-microbiome-metabolome-crosstalk/ Fri, 19 Jun 2026 00:00:00 +0000 https://www.pierre-francois-roux.com/project/skin-microbiome-metabolome-crosstalk/ During my postdoctoral work at Johnson & Johnson, I investigated how the skin microbiome and metabolome jointly contribute to skin physiology, maturation and inflammatory risk. The skin is not only a passive barrier: it is an immuno-metabolic interface continuously exposed to environmental stressors and resident microbial communities. Most microbiome studies focus on taxonomic composition, but microbial function is often mediated through metabolites produced, transformed or degraded at the skin surface. To capture this functional dimension, I integrated 16S rRNA profiling and targeted metabolomics from non-invasive skin surface samples, using multivariate and network-based approaches to connect microbial communities with metabolite patterns. https://www.pierre-francois-roux.com/project/toward-a-systems-view-of-cellular-senescence/ Fri, 27 Apr 2018 00:00:00 +0000 https://www.pierre-francois-roux.com/project/toward-a-systems-view-of-cellular-senescence/ Cellular senescence is a stress response triggered by telomere dysfunction, oncogene activation, DNA damage, oxidative stress and other insults. It leads to a durable proliferative arrest, but also to profound changes in chromatin organization, transcription, metabolism and secretory activity. This dual nature makes senescence biologically fascinating: it contributes to tumor suppression, wound healing and development, yet persistent senescent cells can also promote chronic inflammation, tissue dysfunction, cancer progression and aging-related pathologies.