https://www.pierre-francois-roux.com/tags/motifs/ Recent content in Motifs on Pierre-François Roux Hugo -- gohugo.io en-us © 2021 Pierre-François Roux Fri, 19 Jun 2026 09:50:00 +0000 https://www.pierre-francois-roux.com/2026/06/19/rank-transcription-factors-by-evidence-not-only-by-enrichment/ Fri, 19 Jun 2026 09:50:00 +0000 https://www.pierre-francois-roux.com/2026/06/19/rank-transcription-factors-by-evidence-not-only-by-enrichment/ Motif enrichment is a good starting point, but it is a weak ending point. A motif can be enriched because many related transcription factors share the same binding preference, because the region set is GC-rich, or because accessibility has changed without direct TF binding. When I try to prioritize candidate regulators, I prefer to build an evidence table. Each transcription factor gets several independent scores, and the interesting candidates are those supported by multiple layers.