https://www.pierre-francois-roux.com/tags/cancer/ Recent content in Cancer on Pierre-François Roux Hugo -- gohugo.io en-us © 2021 Pierre-François Roux Fri, 19 Jun 2026 00:00:00 +0000 https://www.pierre-francois-roux.com/project/atac-seq-as-an-integrative-assay-for-aging-and-cancer/ Fri, 19 Jun 2026 00:00:00 +0000 https://www.pierre-francois-roux.com/project/atac-seq-as-an-integrative-assay-for-aging-and-cancer/ ATAC-seq is widely used to map chromatin accessibility, but bulk ATAC-seq libraries contain much more information than accessible regulatory elements alone. In recent work, I benchmarked ATAC-seq against matched whole-genome sequencing to evaluate whether a single assay can also recover genetic information relevant to cancer and aging biology. Using paired datasets from patient-derived melanoma cell lines and TCGA brain tumors, we showed that ATAC-seq can support high-precision small variant detection within accessible regions, robust copy-number profiling, mitochondrial genome characterization and telomere-associated repeat quantification, while preserving its classical epigenomic readouts.